Anatomy:

Research Papers Published:

• Monosomy 20 Mosaicism. A case report. Annual conference All India Society oh Human Genetics, Pune 1984
• Chromosomal abnormalities observed in chronic myeloid leukaemia. All India physicians’ conference, Surat. 1985
• Predictive value of E2 response in Gnrh+HMG super ovulation protocol in IVF cycles.
• Comparison of IVF outcome in cases of ET carried out with and without Ultrasound guidance. A 20 case study report. - International conference on IVF and Infertility under the ages of Indian Society of Assisted Reproduction, Kolkata, 1997.
• Co-relation of low E3 in maternal serum with Trisomy 18 pregnancies.
• A case of 11q-;1p+ balanced translocation carrier father transmitting unbalanced chromosome complement to two of his off springs.
• Co-relation of satellite polymorphism in acrocentrics with unfavourable obstetric outcome. Annual conference All India Society of Human Genetics, AIIMS, New Delhi1998.
• Predictive value of triple foetal markers in maternal blood during first trimester of pregnancy.Gujarat State FOGSI Conference, Surat, 1999.
• Phanindra Prasad Poudel: Comparative study of foetal weight and placental parameters on smoking and nonsmoking Nepalese mothers.
• Chacchu Bhattarai: Comparative Study of thickness of frontal bone on CT scan focusing on pressure distributed area between load carrying and load not carrying Nepalese Population

Undergoing:

• Study on variation of termination external jugular vein by Phanindra Prasad Poudel
• Cytogenetic studies in Infertility. Project funded by MS University of Baroda, Baroda: Principal Investigator Prof. Shrikant Akolekar
• Cytogenetic studies in Chronic Myeloid Leukemia. Project funded by Department of Health Govt. of Gujarat : Principal Investigator Prof. Shrikant Akolekar
• Standardization of A F culture technique for prenatal diagnosis. Project funded by I C M R, New Delhi. : Principal Investigator Prof. Shrikant Akolekar 

Bio-Chemistry

• Ethical clearance is expected for the following research on Troponin ,lipid profiles and Acute Myocardial Infarction- L.D.R., de Silva, Arun Kumar, Brijesh Sathian
• Ferritin in maternal and cord blood L.D.R., de Silva, Arun Kumar,

Microbiology:

• Antibiogram of Staphylococcus aureus (Methicillin resistant and sensitive)
• Characterization of Candida isolates from sputum.
• Bacterial aetiology of LRTI in elderly patients
• HBsAg, HIV, HCV carriers among blood donors
• Prevalence of Shigellosis and antibiogram
• Opportunistic protozoal infections.

Ongoing:
The areas of active research in the department are:

• Antibiotic susceptibility profile of Salmonella isolates.
• Bacteriologic profile of organisms of HAI.
• Predominant flora in Intensive Care Unit and its association with HAI
• DOTS and its role in surveillance
• Helminthic infections in school going children.
• Characterisation and drug susceptibility of Mycobacterium tuberculosis.
• Detection of evolution of multi drug resistant bacteria especially of the GIT
• Epidemiological surveillance of hospital acquired infections
• Formulating effective antibiotic policies
• Parasitological profile in childhood diarrhea
• Effect of environment on the bacteriological and parasitological diseases
• Pulmonary and extra-pulmonary tuberculosis

Pathology

Ongoing Research Projects:

• AgNOR counts – Diagnostic significance in cervical intraepithelial lesions and carcinoma in PAP smears in comparison to histology . ( Oct 2007 ) –Dr. Shiva Raj K. C., Prof OP Talwar
• Mucin histochemisrty in benign and malignant prostatic lesions and its correlation with PSA values. - Dr Shova Bastola , Prof OP Talwar
• Spectrum of histopathological changes in the skin of patients with diabetes mellitus and their clinical correlation in the Western region of Nepal ( Ongoing ) - Dr Suniti Shrestha , Prof OP Talwar
• Value of endometrial aspiration cytology in the diagnosis of perimenopausal bleeding disorders and its correlation with histopathology ( Ongoing ) - Prof OP Talwar , Dr. Shagufta Mirza , Dr. Arnab ghosh,
• Usefulness of image guided FNAC in deep seated lesions - Dr. Seema Pradhan , Dr. Arnab Ghosh , Prof O P Talwar
• Tumors of Neural origin – our expirience ( Ongoing ) - Dr. Arnab Ghosh , Dr. Seema Pradhan , Prof O P Talwar
• Basal Cell Carcinoma – A clinicopathological analysis ( Ongoing ) - Dr. Seema Pradhan , Dr. Arnab Ghosh , Prof O P Talwar
• Analysis of salivary gland neoplasms ( Ongoing )- Dr. Seema Pradhan , Dr. Arnab Ghosh, Prof O P Talwar
• Ocular surface squamous neoplasia in pokhara valley - Dr. Rajesh Pradhan, Dr. Seema Pradhan
• A case of leukaemia presenting as retinal artery occlusion - Dr. Rajesh Pradhan, Dr. Seema Pradhan
• A case of Alder Reilly syndrome- Dr. Seema V Pradhan, Dr. Moinak Sen Gupta
• Anaemia in adolescent girls – a clinicopathological study - Dr. Raju Paudel, Dr. Seema V Pradhan, Dr. Arnab ghosh
• Castleman disease – a study of 5 cases - Dr. Arnab Ghosh, Dr O P Talwar, Dr Seema V Pradhan
• Spectrum of bone marrow changes in Pancytopenia - Dr. Arnab Ghosh, Dr. Seema V Pradhan
• A profile of Hydatid cysts in Manipal Teaching Hospital - Dr. Seema V Pradhan, Dr. Arnab Ghosh
• Study of nucleolar organizer regions in melanoma - Dr. Arnab Ghosh, Dr. Seema V Pradhan
• A case of Adrenal Gland Teratoma in a middle aged woman - Dr. Jalaz Baxi, Dr. Mukta Baxi, Dr. Seema V Pradhan, Dr.Arnab Ghosh, Prof. O.P.Talwar

Pharmacology:

Post graduate research projects:

• A study of adverse drug reactions caused by first line anti- tubercular drugs used in Directly Observed Treatment, Short Course (DOTS) therapy in western Nepal, Pokhara by Ms. Anupa KC during the year 2005
• Utilization of intravenous fluids and intravenous medicines among inpatients by Mr. Sudesh Gyawali during the year 2006
• Impact of educational intervention on pattern of drug - drug interactions in internal medicine wards of a teaching hospital in Nepal by Ms. Durga Bista during the year 2006

Ongoing PhD research projects in the department:

• Mr. P. Subish: Evaluation of the impact of Pharmacovigilacne program in Western Nepal - Registered in : University Sains Malaysia, Malaysia 

• Mr. Dinesh K. Upadhyay: Evaluation of the Pharmaceutical care program for diabetes patients in a teaching hospital in Western Nepal- Registered in: University Sains Malaysia, Malaysia 

• Mr. Kadir Alam: Impact of educational intervention on more Rational use of Medicines - Registered in: Chulolongkorn University, Bangkok, Thailand

Research projects carried out:

• Analysis of drug information services in a teaching hospital in Western Nepal
• Drug utilization in the intensive care unit of a teaching hospital in Western Nepal
• Drug utilization among paediatric inpatients in a teaching hospital in Western Nepal
• Teaching ethical drug promotion using role plays
• Designing a spontaneous ADR reporting form: an exercise for medical students
• Reading habits of medical students: a questionnaire based survey
• Student attitudes towards basic sciences
• Teaching rational use of medicines: Student feedback
• Medical student stress and coping strategies
• Using postgraduate students as simulated patients during communication skills learning and assessment
• Learning style of medical students.
• Activity based learning of pharmacology
• Drug utilization among outpatients in a teaching hospital
• Teaching critical analysis of journal articles.
• Analyzing rationality of prescriptions as a means to inculcating good prescribing habits.
• Drug utilization among geriatric inpatients
• Drug utilization among surgical outpatients
• Medical student attitudes towards the doctor-patient relationship.
• Fluoroquinolone utilization among inpatients in a teaching hospital.
• Pattern and economic impact of cutaneous adverse drug reactions – an experience from the regional pharmacovigilance center, Western Nepal.
• Correct use of metered dose inhaler: a prospective interventional study among healthcare professionals in a Nepalese teaching hospital (In collaboration with Department of Medicine)
• Price variation among oral hypoglycemic agents in a teaching hospital in Nepal
• Postgraduate students as facilitators in problem-stimulated learning microteaching sessions
• Diagnosing Abdominal Tuberculosis: A Retrospective Study From Nepal. (In collaboration with Department of Medicine)
• Knowledge, attitude and practice about diabetes among diabetes patients in Western Nepal
• Impact Of Educational Intervention On Inhaler Techniques: A Pilot Study
• Pattern of potential drug-drug interactions in diabetic out-patients in a tertiary care teaching hospital in Nepal
• Preliminary evaluation of use pattern of pneumococcal vaccine in a developing country- a study of 24 cases in a tertiary care hospital in Nepal.
• Pattern of adverse drug reactions experienced by tuberculosis patients in a tertiary care Teaching hospital in western Nepal
• Learning session on Disease mongering- Student feedback
• Drug utilization pattern in dental outpatients in a tertiary care teaching hospital in Western Nepal
• Utilization of cancer chemotherapeutic agents in a tertiary care teaching hospital in Western Nepal
• Drug utilization with special reference to antimicrobials in a sub health post in western Nepal
• Fluoroquinolone utilization among inpatients in a teaching hospital in Western Nepal
• Evaluation of the impact of pharmacist provided medication counseling in terms of patient perception, expectation and satisfaction with the pharmacists.

Physiology:

• Faculty pursuing research publications in peer reviewed journals in field of Yoga, meditation and anthropometry.
• Mr MG Ramesh Babu. Effect of Raj Yoga on Depressive patients at Brahmakumaris’ Raj yoga centre opened at Manipal Teaching Hospital (MTH). A pilot study before PhD thesis.
• Postgraduate students pursuing PhD in Burdwan University on “Parathyroid gland and calcium regulation”

ENT

• Mallick S, Sharma V, Lavania A, Borgohain B. Allergic fungal sinusitis – case report. Kathmandu University Medical Journal, 6:2, 2008, p 235-238
• Sharma V, Borgohain BN, Mallick SA, Sharma M. Adeno-squamous carcinoma of maxilla – a rare case. Journal of Society of Surgeons of Nepal, 10:1, 2007, p 18-20
• Sharma V. Endoscopic total inferior turbinectomy – research paper. Journal of College of Medical Sciences - Nepal, 3:1, 2006, p 68-71.
• Sharma V, Lavania A, Mallick SA, Sharma M. Ectopic canine tooth: a rare cause for maxillary antral mucocoele. Kathmandu University Medical Journal, 4:2, 2006, p 251-252.
• Sharma V. Rhinitis medicamentosa. Drug Information Bulletin, Department of Clinical
• Pharmacology, College of Medical Sciences, Nepal. 4:2, 2006, p 5-6.
• Sharma V, Lavania A, Mallick SA, Borgohain BN. Isolated Orbital Osteoma – case report. Journal of Society of Surgeons of Nepal, 8:4, 2005, p 35-37.
• Lavania A, Sharma V, Reddy NS, Mallick SA. Maxillary antral pyocoele – rare case. Journal of College of Medical Sciences - Nepal, 2:1, 2005, p 155-156.
• Lavania A, Sharma V, Reddy NS, Baksh R. Orbital cellulitis – a complication of sinusitis. Kathmandu University Medical Journal, 3:3, 2005, p 292-293.

PAPERS SENT FOR PUBLICATION:

• Epiglottic cyst – a case report. Journal of Society of Surgeons of Nepal; First author: Dr. Vishal Sharma
• Impacted glass foreign body in subglottis – original article. Journal of Society of Surgeons of Nepal. First author: Dr. Vishal Sharma
• Combined forceps and Fogarty catheter extraction of an unusual foreign body in oesophagus of an 18-month-old child – case report. Journal of Society of Surgeons of Nepal; First author: Dr. Vishal Sharma

Neuro Surgery:

There have been 4 publications and 9 submissions to Nepalese journals. These articles have been based on the cases that we have seen at the MTH.

Obstetrics & Gynaecology

• Nascent stage project development in association with dept of Biochemistry titled " Co-relation of maternal iron reserve vis-à-vis neonatal iron reserve "
• Evaluation of role of amniofusion in patients of oligohydramnios beyond viability period

Ophthalmology

Lens opacity as a biomarker of exposure on the study of indoor air pollution.
Principal Investigator: Amod Pokhrel, UCLA, Berkeley
Co- investigator: Prof. S.P. Shrestha

Directors:

1. Prof. Kirk Smith, Prof and Head, Dep. Of Environmental Health Science, School of Public Health, University of California at Berkeley.
2. Prof. Lam Bailey, Prof and Head, School of Optometry, University of California at Berkeley.

On going research activities:

• Study on identification of factors affecting the relationship between CCT and Intra Ocular pressure
• A comparative study of tear secretion and tear film instability in patients with pterygium and normal healthy subjects
• Study on ocular changes in patients with diabetes mellitus
• Study on corneal thickness in normal population of western Nepal
• Study on corneal curvature in normal population in Pokhara
• A comparative study of induced astigmatism in SICS by 6-6.5 mm straight and frown incisions

Pediatrics:

• Varied presentation of acute glomerulo nephritis in children in single centre experience from a developing country Dr. K Malla etc SQMJ - 2008
• Syndrome management in HIV AIDS disease in children; Dr. P K Swain, Dr. Anna Thaplial etc. JNPS 2007
• Childhood middle ear tuberculosis, rare case report; Dr. P K Swain, Dr. Anna Thaplial etc. JNPS 2007
• Efficacy of albendazole and short course prednisolone in children with REL of neurocystycerosis : Randomwise control trial JNPS December 2007
• Myelofibrosis in a child with tuberculosis, Dr. K Malla etc JNPS December 2007